Professional Record
| 52 Wins (36 knockouts, 16 decisions), 9 Losses (3 knockouts, 6 decisions), 0 Draw | |||||||
| Res. | Record | Opponent | Type | Rd., Time | Date | Location | Notes |
| Loss | 52-9 | Danny García | KO | 4 (12) | 2012-10-20 | Barclays Center, New York, New York | For WBC & WBA (Super) and The Ring Light Welterweight titles. |
| Loss | 52–8 | Danny García | UD | 12 | 2012-03-24 | Reliant Arena, Houston, Texas | Lost WBC Light Welterweight title on the scale, making the contest titular only for García. |
| Win | 52–7 | Pablo César Cano | TKO | 10 (12), 3:00 | 2011-09-17 | MGM Grand Garden Arena, Las Vegas, Nevada | Won vacant WBC Light Welterweight title. |
| Loss | 51–7 | Marcos Maidana | MD | 12 | 2011-04-09 | MGM Grand Garden Arena, Las Vegas, Nevada | For Interim WBA Light Welterweight title. |
| Win | 51–6 | Francisco Lorenzo | UD | 12 | 2010-12-18 | Agua Caliente Racetrack, Tijuana, Baja California | Retained WBC Silver Light Welterweight title. |
| Win | 50–6 | Willie Limond | KO | 6 (12), 2:46 | 2010-09-11 | Plaza Mexico, Mexico City, Distrito Federal | Won vacant WBC Silver Light Welterweight title. |
| Win | 49–6 | José Alfaro | UD | 12 | 2010-03-27 | Arena Monterrey, Monterrey, Nuevo León | Won vacant WBC International Welterweight title. |
| Loss | 48–6 | David Díaz | UD | 12 | 2007-08-04 | Allstate Arena, Rosemont, Illinois | For WBC Lightweight title. |
| Loss | 48–5 | Manny Pacquiao | KO | 3 (12) 2:57 | 2006-11-18 | Thomas & Mack Center, Las Vegas, Nevada | For WBC International Super Featherweight title. |
| Loss | 48–4 | Manny Pacquiao | TKO | 10 (12), 2:33 | 2006-01-21 | Thomas & Mack Center, Las Vegas, Nevada | For WBC International Super Featherweight title. |
| Loss | 48–3 | Zahir Raheem | UD | 12 | 2005-09-10 | Staples Center, Los Angeles, California | For vacant WBC International Lightweight title. |
| Win | 48–2 | Manny Pacquiao | UD | 12 | 2005-03-19 | MGM Grand Garden Arena, Las Vegas, Nevada | Won vacant WBC International & vacant IBA Super Featherweight title. |
| Loss | 47–2 | Marco Antonio Barrera | MD | 12 | 2004-11-27 | MGM Grand Garden Arena, Las Vegas, Nevada | Lost WBC Super Featherweight title. The Ring magazine's "Fight of the Year" (2004) |
| Win | 47–1 | Carlos Hernández | UD | 12 | 2004-07-31 | MGM Grand Garden Arena, Las Vegas, Nevada | Retained WBC & won IBF Super Featherweight titles. |
| Win | 46–1 | Jesús Chávez | UD | 12 | 2004-02-28 | MGM Grand Garden Arena, Las Vegas, Nevada | Won WBC Super Featherweight title. |
| Win | 45–1 | Guty Espadas, Jr. | KO | 3 (12), 2:58 | 2003-10-04 | Staples Center, Los Angeles, California | WBC Super Featherweight Title Eliminator. |
| Win | 44–1 | Fernando Velárdez | TKO | 5 (12), 1:02 | 2003-07-31 | Mandalay Bay Resort & Casino, Las Vegas, Nevada | Retained WBC Featherweight title. |
| Win | 43–1 | Edward Lee Croft | TKO | 3 (12), 2:16 | 2003-2-22 | Plaza Mexico, Mexico City, Distrito Federal | Retained WBC Featherweight title. |
| Win | 42–1 | Paulie Ayala | UD | 12 | 2002-11-16 | Mandalay Bay Resort & Casino, Las Vegas, Nevada | Won vacant WBC Featherweight title. |
| Loss | 41–1 | Marco Antonio Barrera | MD | 12 | 2002-06-22 | MGM Grand Garden Arena, Las Vegas, Nevada | Lost WBC Featherweight title. For vacant The Ring Featherweight title. |
| Win | 41–0 | In-Jin Chi | UD | 12 | 2002-07-31 | Staples Center, Los Angeles, California | Retained WBC Featherweight title. |
| Win | 40–0 | Guty Espadas, Jr. | UD | 12 | 2001-02-17 | MGM Grand Garden Arena, Las Vegas, Nevada | Won WBC Featherweight title. |
| Win | 39–0 | Rodney Jones | KO | 1 (10), 1:02 | 2000-12-09 | Auditorio Municipal, Tijuana, Baja California | |
| Win | 38–0 | Kevin Kelley | TKO | 7 (12), 2:30 | 2000-09-02 | Don Haskins Convention Center, El Paso, Texas | Won Interim WBC Featherweight title. |
| Win | 37–0 | Michael Leroy Juárez | KO | 3 (10), 1:12 | 2000-06-17 | Staples Center, Los Angeles, California | |
| Win | 36–0 | Marco Antonio Barrera | SD | 12 | 2000-02-19 | Mandalay Bay Events Center, Las Vegas, Nevada | Retained WBC & won WBO Super Bantamweight titles. The Ring magazine's "Fight of the Year" (2000) |
| Win | 35–0 | Wayne McCullough | UD | 12 | 1999-10-22 | Joe Louis Arena, Detroit, Michigan | Retained WBC Super Bantamweight title. |
| Win | 34–0 | Reynante Jamili | TKO | 6 (12), 0:11 | 1999-07-31 | Plaza de Toros, Tijuana, Baja California | Retained WBC Super Bantamweight title. |
| Win | 33–0 | Juan Carlos Ramírez | TKO | 9 (12), 0:28 | 1999-05-08 | Hilton Hotel, Las Vegas, Nevada | Retained WBC Super Bantamweight title. |
| Win | 32–0 | Ángel Chacón | KO | 2 (12), 1:50 | 1999-02-13 | Thomas & Mack Center, Las Vegas, Nevada | Retained WBC Super Bantamweight title. |
| Win | 31–0 | Junior Jones | KO | 4 (12), 2:55 | 1998-09-12 | Plaza de Toros, Tijuana, Baja California | Retained WBC Super Bantamweight title. |
| Win | 30–0 | José Luis Bueno | KO | 2 (12), 1:19 | 1998-05-16 | Plaza de Toros, Tijuana, Baja California | Retained WBC Super Bantamweight title. |
| Win | 29–0 | Remigio Molina | TKO | 6 (12), 0:14 | 1998-04-03 | Tijuana, Baja California | Retained WBC Super Bantamweight title. |
| Win | 28–0 | John Lowey | TKO | 7 (12), 3:00 | 1997-12-12 | Auditorio Municipal, Tijuana, Baja California | Retained WBC Super Bantamweight title. |
| Win | 27–0 | Daniel Zaragoza | KO | 11 (12), 2:59 | 1997-09-06 | County Coliseum, El Paso, Texas | Won WBC Super Bantamweight title. |
| Win | 26–0 | Concepcion Velásquez | TKO | 8 (10), 1:11 | 1997-04-04 | Orleans Hotel & Casino, Las Vegas, Nevada | |
| Win | 25–0 | Robbie Lovato | UD | 10 | 1996-11-29 | Tijuana, Baja California | |
| Win | 24–0 | Pedro Javier Torres | KO | 2 (12), 1:50 | 1996-10-12 | Arrowhead Pond, Anaheim, California | Retained NABF Super Bantamweight title. |
| Win | 23–0 | Hector Acero Sánchez | UD | 12 | 1996-06-07 | Caesars Palace, Las Vegas, Nevada | Retained NABF Super Bantamweight title. |
| Win | 22–0 | Lee Cargle | TKO | 2 (10), 0:11 | 1996-04-22 | Tijuana, Baja California | Retained NABF Super Bantamweight title. |
| Win | 21–0 | Rudy Bradley | TKO | 11 (12), 0:02 | 1996-02-25 | Arizona Charlie's, Las Vegas, Nevada | Retained NABF Super Bantamweight title. |
| Win | 20–0 | Kenny Mitchell | TKO | 2 (12), 2:30 | 1995-12-18 | Tijuana, Baja California | Retained NABF Super Bantamweight title. |
| Win | 19–0 | Enrique Angeles | UD | 12 | 1995-11-10 | Tijuana, Baja California | Retained NABF & Mexico Super Bantamweight titles. |
| Win | 18–0 | Alberto Martínez | TKO | 4 (12), 0:42 | 1995-09-09 | Caesars Palace, Las Vegas, Nevada | Retained NABF Super Bantamweight title. |
| Win | 17–0 | Juan Luis Torres | UD | 12 | 1995-07-14 | Las Vegas, Nevada | Won vacant NABF Super Bantamweight title. |
| Win | 16–0 | Armando Castro | TKO | 10 (12), 1:04 | 1995-06-02 | Tijuana, Baja California | Retained WBC Mundo Hispano Super Bantamweight title. |
| Win | 15–0 | Enrique Jupiter | TKO | 6 (12), 0:28 | 1995-04-21 | Tijuana, Baja California | Won Mexico Super Bantamweight title. |
| Win | 14–0 | Ricky Hernández | KO | 1 (12), 0:14 | 1995-02-03 | Tijuana, Baja California | Retained WBC Mundo Hispano Super Bantamweight title. |
| Win | 13–0 | José Valdez | TKO | 3 (12), 2:14 | 1994-12-19 | Tijuana, Baja California | Won WBC Mundo Hispano Super Bantamweight title. |
| Win | 12–0 | Ramón Magana | TKO | 2 (8), 1:19 | 1994-11-28 | Tijuana, Baja California | |
| Win | 11–0 | Idelfonso Bernal | KO | 3 (8), 0:21 | 1994-10-17 | Tijuana, Baja California | |
| Win | 10–0 | Julio César Cardona | KO | 2 (8), 1:01 | 1994-08-22 | Tijuana, Baja California | |
| Win | 9–0 | Isidro Nolasco | UD | 8 | 1994-03-26 | Mexico City, Distrito Federal | |
| Win | 8–0 | Paul Olvera | KO | 3 (6), 2:55 | 1994-01-21 | Tijuana, Baja California | |
| Win | 7–0 | Alfonso Mota | KO | 2 (6), 1:19 | 1993-12-06 | Tijuana, Baja California | |
| Win | 6–0 | Jaime Abrica | KO | 2 (6), 0:03 | 1993-10-22 | Tijuana, Baja California | |
| Win | 5–0 | José Álvarez | UD | 6 | 1993-07-26 | Tijuana, Baja California | |
| Win | 4–0 | Marco Tovar | TKO | 1 (4), 0:59 | 1993-07-08 | Plaza de Toros, Tijuana, Baja California | |
| Win | 3–0 | Óscar Maldonado | KO | 3 (4), 0:32 | 1993-05-25 | Tijuana, Baja California | |
| Win | 2–0 | Jaime Rodríguez | KO | 2 (4), 1:11 | 1993-05-07 | Tijuana, Baja California | |
| Win | 1–0 | José Orejel | KO | 2 (4), 0:19 | 1993-03-29 | Tijuana, Baja California | Morales' Professional Debut at 16 years old. |
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