Eosinophil peroxidase is a haloperoxidase enzyme that in humans is encoded by the EPX gene. The enzyme is a heterodimeric 71-77 kD peroxidase consisting of a heavier glycosylated chain and a lighter nonglycosylated chain. This enzyme prefers bromide over chloride as a substrate, converting it to toxic hypobromite.
| Eosinophil peroxidase | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||||
| Symbols | EPX; EPO; EPP; EPX-PEN | ||||||||||
| External IDs | OMIM: 131399 MGI: 107569 HomoloGene: 20144 ChEMBL: 2438 GeneCards: EPX Gene | ||||||||||
| EC number | 1.11.1.7 | ||||||||||
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| Orthologs | |||||||||||
| Species | Human | Mouse | |||||||||
| Entrez | 8288 | 13861 | |||||||||
| Ensembl | ENSG00000121053 | ENSMUSG00000052234 | |||||||||
| UniProt | P11678 | P49290 | |||||||||
| RefSeq (mRNA) | NM_000502.4 | NM_007946.2 | |||||||||
| RefSeq (protein) | NP_000493.1 | NP_031972.2 | |||||||||
| Location (UCSC) | Chr 17: 56.27 – 56.28 Mb |
Chr 11: 87.86 – 87.88 Mb |
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| PubMed search | |||||||||||
Read more about Eosinophil Peroxidase: Function, Role in Pathology
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