Cast
- Jonny Lee Miller as Eli Stone, a successful attorney in San Francisco who is diagnosed with an inoperable brain aneurysm which is causing hallucinations. The hallucinations cause Eli to become alienated from his peers and soon his life takes a detour. Despite the fact that he is not religious, he interprets his hallucinations as signs, helping people in accepting lawsuits in hopes of bettering their lives.
- Young Eli is played by Justin Lieberman.
- Natasha Henstridge as Taylor Wethersby, Eli's ex-fiancee who is also an attorney. She formerly works in another company, and later joins in Eli's firm after they broke up. Although taken aback by Eli's episodes of hallucinations, she is determined to help him at any means. She is the daughter of Jordan Wethersby, the head of Wethersby, Posner & Klein.
- Loretta Devine as Patti Dellacroix, Eli's helpful and bossy assistant. She considers Eli as a dear friend of hers and she is always blatantly honest to Eli.
- Matt Letscher as Dr. Nathan Stone, Eli's caring elder brother who is a doctor. He is the first who discovered Eli's conditions and he is also skeptical about his visions. Nathan dated Beth, a girl who Eli lost his virginity to in college, after Eli introduced both of them to each other at his engagement party.
- Sam Jaeger as Matt Dowd, Eli's co-worker and rival in the law firm. He is described as sarcastic, arrogant and having a frat-boy personality. He is dating Taylor Wethersby and they are going to have a baby.
- James Saito as Dr. Chen, an acupuncturist who explains Eli's conditions as a prophetic message. He helps Eli to analyze the visions Eli has and advises Eli to pursue them. He studied acupuncture in Beijing as well as holistic medicine. It is revealed that he is not a Chinese immigrant, and the "Dr. Chen" is merely an act so he will be taken seriously because, "No one trusts an acupuncturist from New Jersey". He once worked for Eli's father, who told him once that he would repay a favor by helping his son (Eli) someday.
- Julie Gonzalo as Maggie Dekker, a junior attorney who is ambitious and enthusiastic to her work. Much to Eli's dismay, she often assists him in his cases in hopes of moving up the career ladder. She is considered a religious person who is the first person to believe in Eli's visions without hesitations. She was engaged to Scott, who is in Eli's visions of the earthquake.
- Jason Winston George as Keith Bennett, a criminal law attorney who sued a potential employer for racism. After Keith lost the lawsuit, Jordan hired him as he saw Keith's potential.
- Victor Garber as Jordan Wethersby, the co-owner of the firm and Taylor's father. He is often skeptical of Eli's imaginings. However, he is a mentor and father figure to Eli, and represented Eli when Eli was brought before the bar for allegedly being unable to represent clients' interests while suffering visions.
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