Selection Effective Size
In an idealised Wright-Fisher model, the fate of an allele, beginning at an intermediate frequency, is largely determined by selection if the selection coefficient s >> 1/N, and largely determined by neutral genetic drift if s << 1/N. In real populations, the cutoff value of s may depend instead on local recombination rates. This limit to selection in a real population may be captured in a toy Wright-Fisher simulation through the appropriate choice of Ne. Populations with different selection effective population sizes are predicted to evolve profoundly different genome architectures.
Read more about this topic: Effective Population Size
Famous quotes containing the words selection, effective and/or size:
“The books for young people say a great deal about the selection of Friends; it is because they really have nothing to say about Friends. They mean associates and confidants merely.”
—Henry David Thoreau (1817–1862)
“Watteau is no less an artist for having painted a fascia board while Sainsbury’s is no less effective a business for producing advertisements which entertain and educate instead of condescending and exploiting.”
—Stephen Bayley (b. 1951)
“One writes of scars healed, a loose parallel to the pathology of the skin, but there is no such thing in the life of an individual. There are open wounds, shrunk sometimes to the size of a pin-prick but wounds still. The marks of suffering are more comparable to the loss of a finger, or the sight of an eye. We may not miss them, either, for one minute in a year, but if we should there is nothing to be done about it.”
—F. Scott Fitzgerald (1896–1940)