Selection Effective Size
In an idealised Wright-Fisher model, the fate of an allele, beginning at an intermediate frequency, is largely determined by selection if the selection coefficient s >> 1/N, and largely determined by neutral genetic drift if s << 1/N. In real populations, the cutoff value of s may depend instead on local recombination rates. This limit to selection in a real population may be captured in a toy Wright-Fisher simulation through the appropriate choice of Ne. Populations with different selection effective population sizes are predicted to evolve profoundly different genome architectures.
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