Edward Seymour may refer to:
- Edward Seymour, 1st Duke of Somerset, Lord Protector of England (1547-49), during the minority of his nephew, Edward VI of England
- Edward Seymour, 1st Earl of Hertford, son of the above
- Sir Edward Seymour, of Berry Pomeroy, Sheriff of Devon, son of the first
- Edward Seymour, Lord Beauchamp of Hache
- Sir Edward Seymour, 1st Baronet (c.1563–1613), English MP
- Sir Edward Seymour, 2nd Baronet (c.1580–1659), English MP
- Sir Edward Seymour, 3rd Baronet (1610–1688), English MP
- Sir Edward Seymour, 4th Baronet (1633–1708), an English statesman who served as Treasurer of the Navy during the First Danby Ministry
- Sir Edward Seymour, 5th Baronet (1663–1740), English MP
- Edward Seymour, 8th Duke of Somerset
- Edward Seymour, 9th Duke of Somerset
- Edward St Maur, 11th Duke of Somerset
- Edward Seymour, 12th Duke of Somerset
- Edward Seymour, 16th Duke of Somerset
- Edward A. Seymour (1887–1965), Wisconsin State Assemblyman
- Edward Woodruff Seymour (1832–1892), Connecticut state representative
- Sir Edward Hobart Seymour, British admiral active during the Boxer Rebellion
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