Edward Murphy or Ed Murphy may refer to:
- Eddie Murphy (born 1961), actor and comedian
- Edward Murphy (New York politician) (1836–1911), U.S. senator from New York, and mayor of Troy, New York
- Ned Murphy (fl. 1880s), Irish sportsman
- Edward A. Murphy, Jr. (1918–1990), American aerospace engineer, namesake of "Murphy's Law"
- Edward Preston Murphy (1904–1958), U.S. federal judge
- Edward Murphy (Medal of Honor) (died 1924), U.S. Army private, Medal of Honor recipient for actions during the Indian Wars in 1869
- Edward F. Murphy (died 1908), U.S. Army corporal, Medal of Honor recipient for actions during the Indian Wars in 1879
- Edward Sullivan Murphy (1880–1945), Northern Irish politician
- Edward Murphy (rower) (born 1971), American rower
- Edward Murphy (politician) (1818–1895), Canadian senator
- Ed Murphy (soccer) (born 1930), Scottish-born soccer player, played for the U.S. national team, 1955–1969
- Ed Murphy (first baseman) (1918–1991), baseball player for the Philadelphia Phillies
- Ed Murphy (pitcher) (1877–1935), baseball player for the Philadelphia Phillies
- Ed Murphy (activist) (born 1945), American activist
- Ed Murphy (basketball coach) (born 1941), American college basketball coach
Famous quotes containing the words edward and/or murphy:
“Let’s go somewhere where we can be alone. Ah, there doesn’t seem to be anyone on this couch.”
—Irving Brecher, U.S. screenwriter, and Edward Buzzell. S. Quentin Quale (Groucho Marx)
“Narcotics have been systematically scapegoated and demonized. The idea that anyone can use drugs and escape a horrible fate is an anathema to these idiots. I predict that in the near future, right wingers will use drug hysteria as a pretext to set up an international police apparatus.”
—Gus Van Sant, U.S. screenwriter and director, and Dan Yost. Father Tom Murphy (William S. Burroughs)