Toxicology
In several studies, application of high concentrations of some brands of bergamot oil directly to the skin was shown to increase redness after exposure to ultraviolet light; however, this should not apply to ordinary oral consumption of Earl Grey tea. Bergamot is a source of bergamottin which, along with the chemically related compound 6’,7’-dihydroxybergamottin, is known to be responsible for the grapefruit juice effect in which the consumption of the juice affects the metabolism of a variety of pharmaceutical drugs.
In one case study, a patient who consumed four litres of Earl Grey tea per day reported muscle cramps, which were attributed to the function of the bergapten in bergamot oil as a potassium channel blocker. The symptoms subsided upon reducing his consumption of Earl Grey tea to one litre per day.
Read more about this topic: Earl Grey Tea