Clinical Significance
Because of the epigenetic effects of the DNMT family, some DNMT inhibitors are under investigation for treatment of some cancers :
- Vidaza (5-azacitidine) in a phase II trial for AML
- Dacogen (decitabine) in phase III trials for AML and CML
Read more about this topic: DNA Methyltransferase
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“To grasp the full significance of life is the actor’s duty, to interpret it is his problem, and to express it his dedication.”
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