Disseminated Intravascular Coagulation - Causes

Causes

DIC can occur in the following conditions:

• Cancers of lung, pancreas, prostate and stomach, as well as acute myeloid leukemia (particularly APL)
• Obstetric: abruptio placentae, pre-eclampsia, amniotic fluid embolism
• Massive tissue injury: Trauma, burns, extensive surgery
• Infections: Gram-negative sepsis, Neisseria meningitidis, Streptococcus pneumoniae, malaria, histoplasmosis, aspergillosis, Rocky mountain spotted fever
• Miscellaneous: Liver disease, snake bite, giant hemangioma, shock, heat stroke, vasculitis, aortic aneurysm, Serotonin syndrome
• Viral: Arenaviruses causing Argentine hemorrhagic fever or Bolivian Hemorrhagic Fever