Members
| Drug | Mechanism |
|---|---|
| adalimumab | TNF inhibitor |
| azathioprine | Purine synthesis inhibitor |
| chloroquine and hydroxychloroquine (antimalarials) | Suppression of IL-1 & TNF-alpha, induce apoptosis of inflammatory cells and decrease chemotaxis |
| ciclosporin (Cyclosporin A) | calcineurin inhibitor |
| D-penicillamine | Reducing numbers of T-lymphocytes etc. |
| etanercept | TNF inhibitor |
| golimumab | TNF inhibitor |
| gold salts (sodium aurothiomalate, auranofin) | unknown - proposed mechanism: inhibits macrophage activation |
| infliximab | TNF inhibitor |
| leflunomide | Pyrimidine synthesis inhibitor |
| methotrexate (MTX) | Purine metabolism inhibitor |
| minocycline | 5-LO inhibitor |
| rituximab | chimeric monoclonal antibody against CD20 on B-cell surface |
| sulfasalazine (SSZ) | Suppression of IL-1 & TNF-alpha, induce apoptosis of inflammatory cells and increase chemotactic factors |
Although these agents operate by different mechanisms, many of them can have similar impact upon the course of a condition.
Some of the drugs can be used in combination.
Read more about this topic: Disease-modifying Antirheumatic Drug
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