Members
| Drug | Mechanism |
|---|---|
| adalimumab | TNF inhibitor |
| azathioprine | Purine synthesis inhibitor |
| chloroquine and hydroxychloroquine (antimalarials) | Suppression of IL-1 & TNF-alpha, induce apoptosis of inflammatory cells and decrease chemotaxis |
| ciclosporin (Cyclosporin A) | calcineurin inhibitor |
| D-penicillamine | Reducing numbers of T-lymphocytes etc. |
| etanercept | TNF inhibitor |
| golimumab | TNF inhibitor |
| gold salts (sodium aurothiomalate, auranofin) | unknown - proposed mechanism: inhibits macrophage activation |
| infliximab | TNF inhibitor |
| leflunomide | Pyrimidine synthesis inhibitor |
| methotrexate (MTX) | Purine metabolism inhibitor |
| minocycline | 5-LO inhibitor |
| rituximab | chimeric monoclonal antibody against CD20 on B-cell surface |
| sulfasalazine (SSZ) | Suppression of IL-1 & TNF-alpha, induce apoptosis of inflammatory cells and increase chemotactic factors |
Although these agents operate by different mechanisms, many of them can have similar impact upon the course of a condition.
Some of the drugs can be used in combination.
Read more about this topic: Disease-modifying Antirheumatic Drug
Famous quotes containing the word members:
“Consider the value to the race of one-half of its members being enabled to throw aside the intolerable bondage of ignorance that has always weighed them down!”
—Bertha Honore Potter Palmer (1849–1918)
“...wasting the energies of the race by neglecting to develop the intelligence of the members to whom its most precious resources must be entrusted, already seems a childish absurdity.”
—Anna Eugenia Morgan (1845–1909)
“The members of a body-politic call it “the state” when it is passive, “the sovereign” when it is active, and a “power” when they compare it with others of its kind. Collectively they use the title “people,” and they refer to one another individually as “citizens” when speaking of their participation in the authority of the sovereign, and as “subjects” when speaking of their subordination to the laws of the state.”
—Jean-Jacques Rousseau (1712–1778)