Influencing Future Science
The most important influence, however, was the first precept, which states, in Descartes words," never to accept anything for true which I did not clearly know to be such".
This method of pro-foundational skepticism is considered by some to be the start of modern philosophy.
Read more about this topic: Discourse On The Method
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“After sitting in my chamber many days, reading the poets, I have been out early on a foggy morning and heard the cry of an owl in a neighboring wood as from a nature behind the common, unexplored by science or by literature.”
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