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Destiny met Chronos, Walker Gabriel in Chronos # 9, where it is revealed his book can be changed, and entire sections can be warped or erased, albeit at great personal cost; this applies with even more force when a time traveller such as Gabriel attempts to change the timestream to satisfy a personal wish. In Gabriel's case, he manages to save his mother from an early death, but in the process erased himself from history. Destiny also met Lobo and Supergirl in his labyrinth in The Brave and the Bold volume 2, #4. He is more nervous and absent-minded in his demeanor, as a result of having to give up his book.
Destiny lost the Book of Destiny in the opening storyline of the new Brave and the Bold series, and when Lobo and Supergirl arrive in his garden he speaks about how it was intended to reach the four men who existed outside its pages, in the process waylaid by the Luck Lords in a bid to reshape reality. As it turns out, the Challengers of the Unknown were these men, the recipients Destiny had sent it off to be procured by. After a struggle between all factions at the culmination of the arc, the Challengers arrive by Zeta Beam to Rann and acquire the book after defeating the opposition and defeating the Luck Lords. After, it was to be in their care.
After this arc, the book remained in the Challengers' hands; the Challs consulted it to follow the plan of an ancient alchemist, Megistus. Within the pages, they followed the stories of several relics Megistus sought for a master plan; amongst these were some of the most dangerous objects on the DCU. The Warlock of Ys, an old Antimatter Universe foe, even manifested on Challenger Mountain by constructing a shell for himself out of the pages of the book. Destiny himself appeared in the underground lair of the Challs, showing them his book for the final time as a reward for their sacrifice and service in defeating Megistus, in issue #12; the book revealed June Masters, an unofficial member of the Challengers, had cheated Death and managed to escape, blasting herself out of the book much like the Challengers.
Read more about this topic: Destiny (DC Comics)