History
Dendritic spines were first described at the end of the 19th century by Santiago Ramon y Cajal on cerebella neurons. Ramón y Cajal then proposed that dendritic spines could serve as contacting sites between neurons. This was demonstrated more than 50 years later thanks to the emergence of electron microscopy. Until the development of confocal microscopy on living tissues, it was commonly admitted that spine were formed during embryonic development and then would remain stable after birth. In this paradigm, variations of synaptic weight were considered as sufficient to explain memory processes at the cellular level. But since about a decade, new techniques of confocal microscopy demonstrated that dendritic spines are indeed motile and dynamic structures that undergo a constant turnover, even after birth.
Read more about this topic: Dendritic Spine
Famous quotes containing the word history:
“Every literary critic believes he will outwit history and have the last word.”
—Mason Cooley (b. 1927)
“It is my conviction that women are the natural orators of the race.”
—Eliza Archard Connor, U.S. suffragist. As quoted in History of Woman Suffrage, vol. 4, ch. 9, by Susan B. Anthony and Ida Husted Harper (1902)
“Culture, the acquainting ourselves with the best that has been known and said in the world, and thus with the history of the human spirit.”
—Matthew Arnold (1822–1888)