De Palma or DePalma may refer to:
- Anthony DePalma (1904–2005), American surgeon, humanitarian and teacher
- Brian De Palma (born 1940), American film director and writer
- Dan DePalma (born 1989), American football player
- Esteban de Palma (born 1967), Argentinian volleyball player
- Gary DePalma (born 1976), American soccer player
- Gregory DePalma (1932–2009), American convicted criminal
- John DePalma (1885–1951), Italian-born American racing driver
- Joseph-François Charpentier de Cossigny de Palma (1736–1809), French engineer and explorer
- Jula de Palma (born 1932), Italian singer
- Larry DePalma (born 1965), American ice hockey player
- Piero de Palma (born 1916), Italian singer
- Ralph DePalma (1882–1956), Italian-American race driver
- Rossy de Palma (born 1964), Spanish actress and model
- Samuel De Palma (1918–2002), American diplomat
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