De Lugo (of Lugo) can refer to several people who were related to the Spanish city of Lugo:
- Alonso Fernández de Lugo, d.1525, a Spanish conquistador
- Francisco de Lugo, 1580-1652, Spanish Jesuit, theologician
- John de Lugo, 1583-1660, Spanish Jesuit, cardinal
- Ron de Lugo, b.1930, US politician
There are also Dukes of Lugo:
- Infanta Elena, Duchess of Lugo, b.1963, Spanish noble
- Jaime de Marichalar, Duke of Lugo, b.1963, Spanish noble