Daud Khan may refer to:
- Mohammed Daoud Khan, President of the Republic of Afghanistan
- Nawab Daud Khan, Nawab of Carnatic
- David XI of Kartli, aka Daud Khan of Kartli, Muslim Georgian king (16th century)
- Daud Khan Undiladze, a Georgian official in the Iranian service (17th century)
- Daud Khan of Khandesh.