Cytochrome C

Cytochrome C

Identifiers Symbols CYCS; CYC; HCS; THC4 External IDs OMIM: 123970 MGI: 88578 HomoloGene: 68675 GeneCards: CYCS Gene

Gene Ontology
Molecular function	• protein serine/threonine phosphatase activity • iron ion binding • protein binding • heme binding • electron transporter, transferring electrons from CoQH2-cytochrome c reductase complex and cytochrome c oxidase complex activity
Cellular component	• protein phosphatase type 2A complex • nucleus • mitochondrial inner membrane • mitochondrial intermembrane space • cytosol • respiratory chain
Biological process	• apoptotic DNA fragmentation • apoptotic process • activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c • respiratory electron transport chain • small molecule metabolic process • cellular respiration
Sources: Amigo / QuickGO

RNA expression pattern More reference expression data Orthologs Species Human Mouse Entrez 54205 13063 Ensembl ENSG00000172115 ENSMUSG00000058927 UniProt P99999 P62897 RefSeq (mRNA) NM_018947.5 NM_007808.4 RefSeq (protein) NP_061820.1 NP_031834.1 Location (UCSC) Chr 7:
25.16 – 25.16 Mb Chr 19:
24.88 – 24.88 Mb PubMed search

The Cytochrome complex, or cyt c is a small heme protein found loosely associated with the inner membrane of the mitochondrion. It belongs to the cytochrome c family of proteins. Cytochrome c is a highly soluble protein, unlike other cytochromes, with a solubility of about 100 g/L and is an essential component of the electron transport chain, where it carries one electron. It is capable of undergoing oxidation and reduction, but does not bind oxygen. It transfers electrons between Complexes III (Coenzyme Q - Cyt C reductase) and IV (Cyt C oxidase). In humans, cytochrome c is encoded by the CYCS gene.