History
Moses Cleaveland, a surveyor charged with exploring the Connecticut Western Reserve, first arrived at the mouth of the Cuyahoga River in 1796, and subsequently decided to locate a settlement there, which became Cleveland, Ohio.
The river was one of the features along which the "Greenville Treaty Line" ran beginning in 1795, per the Treaty of Greenville, effectively becoming the western boundary of the United States and remaining as such briefly.
Read more about this topic: Cuyahoga River
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