In 1968 came Cream's third release, Wheels of Fire, which topped the American charts. Wheels of Fire studio recordings showcased Cream moving slightly away from the blues and more towards a semi-progressive rock style highlighted by odd time signatures and various orchestral instruments. However, the band did record Howlin' Wolf's "Sitting on Top of the World" and Albert King's "Born Under A Bad Sign". According to a BBC interview with Clapton, the record company, also handling Albert King, asked the band to cover "Born Under a Bad Sign", which became a popular track off the record. The opening song, "White Room", became a radio staple. Another song, "Politician", was written by the band while waiting to perform live at the BBC. The album's second disc featured three live recordings from the Winterland Ballroom and one from the Fillmore. Eric Clapton's second solo from "Crossroads" has made it to the top 20 in multiple "greatest guitar solo" lists.
After the completion of Wheels of Fire in mid-1968, the band members had had enough and wanted to go their separate ways. Baker stated in a 2006 interview with Music Mart magazine, "It just got to the point where Eric said to me: 'I've had enough of this,' and I said so have I. I couldn't stand it. The last year with Cream was just agony. It damaged my hearing permanently, and today I've still got a hearing problem because of the sheer volume throughout the last year of Cream. But it didn't start off like that. In 1966, it was great. It was really a wonderful experience musically, and it just went into the realms of stupidity." Bruce and Baker's combustible relationship proved even worse as a result of the strain put upon the band by non-stop touring, forcing Clapton to play the perpetual role of peacekeeper.
Clapton had also fallen under the spell of Bob Dylan's former backing group, now known as The Band, and their debut album, Music from Big Pink, which proved to be a welcome breath of fresh air in comparison to the incense and psychedelia that had informed Cream. Furthermore, he had read a scathing Cream review in Rolling Stone, a publication he had much admired, in which the reviewer, Jon Landau, called him a "master of the blues cliché." In the wake of that article, Clapton wanted to end Cream and pursue a different musical direction.
At the beginning of their farewell tour on 4 October 1968, in Oakland, nearly the entire set consisted of songs from Wheels of Fire: "White Room", "Politician", "Crossroads", "Spoonful", "Deserted Cities of the Heart", and "Passing the Time" taking the place of "Toad" for a drum solo. "Passing the Time" and "Deserted Cities" were quickly removed from the setlist and replaced by "Sitting on Top of the World" and "Toad".
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