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Pitchers
- 37 Cody Allen
- 51 Scott Barnes
- 59 Carlos Carrasco
- 58 Jeanmar Gómez
- -- Trey Haley
- 56 Frank Herrmann
- -- T. J. House
- 31 David Huff
- 30 Ubaldo Jiménez
- 28 Corey Kluber
- -- Chen-Chang Lee
- 63 Justin Masterson
- 34 Zach McAllister
- 54 Chris Perez
- 53 Rafael Pérez
- 52 Vinnie Pestano
- 67 Danny Salazar
- 44 Chris Seddon
- 49 Tony Sipp
- 38 Joe Smith
- 43 Josh Tomlin
- -- Blake Wood
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Catchers
- 6 Lou Marson
- 41 Carlos Santana
Infielders
- -- Lars Anderson
- -- Mike Avilés
- 13 Asdrúbal Cabrera
- 8 Lonnie Chisenhall
- 29 Juan Díaz
- 16 Jason Donald
- -- Yan Gomes
- 9 Jack Hannahan
- 22 Jason Kipnis
- 46 Cord Phelps
Outfielders
- 23 Michael Brantley
- 4 Russ Canzler
- 12 Ezequiel Carrera
- 17 Shin-Soo Choo
- -- Tim Fedroff
- 36 Thomas Neal
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Pitchers
Catchers
Infielders
Outfielders
- -- Matt Carson
- -- Cedric Hunter
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Manager
- 47 Terry Francona (manager)
Coaches
- 15 Sandy Alomar, Jr. (bench coach)
- -- Mickey Callaway (pitching coach)
- -- Kevin Cash (bullpen coach)
- 2 Brad Mills (third base/outfielders coach)
- -- Mike Sarbaugh (first base/infielders coach)
- -- Ty Van Burkleo (hitting coach)
- 60 Francisco Morales (bullpen catcher)
- 64 Armando Camacaro (bullpen catcher)
- -- Adam Everett (special assistant)
Restricted list
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