Church of God With Signs Following

The Church of God with Signs Following is the name applied to Pentecostal Holiness churches that practice snake handling and drinking poison in worship services, based on an interpretation of the following biblical passage:

"And these signs shall follow them that believe; In my name shall they cast out devils; they shall speak with new tongues; They shall take up serpents; and if they drink any deadly thing, it shall not hurt them; they shall lay hands on the sick, and they shall recover," —Mark 16:17-18

The exact membership is unknown, and has recently been estimated as low as 1,000 and as high as 5,000 with possibly fifty to a hundred congregations. According to the Encyclopedia of American Religions, churches "can be found from central Florida to West Virginia and as far west as Columbus, Ohio." The snake-handling sect of beliefs and practices go as far as to cross the border into Western Canada in 2004 to Lethbridge and Edmonton, Alberta. Each church body is independent and autonomous, and the denominational name is not consistent in all areas, although it is almost always some variation of the name "Church of God" (Trinitarian) or "Church of Jesus" (Non-Trinitarian).

The practice of handling snakes has been made illegal in a number of states. In Tennessee, it is illegal to display any venomous reptile in a manner that endangers anyone. Alabama has a similar statute. In Kentucky, it is illegal to display any reptile at a religious ceremony. Prosecutions, however, are rare.

Documentary films have been made featuring snake-handling, such as Holy Ghost People and Heaven Come Down.