Chromosome 15q partial deletion is an extremely rare human genetic disorder, caused by a chromosomal aberration in which the long ("q") arm of one copy of chromosome 15 is deleted, or partially deleted. If the mother's copy of the chromosomal arm is deleted, Angelman syndrome results. If the father's copy of the chromosomal arm is deleted, Prader-Willi syndrome results. The smallest observed region that can result in these syndromes when deleted is therefore called the PWS/AS critical region and is situated at 15q11-q13. In addition to deletions, uniparental disomy of chromosome 15 gives rise to the same genetic disorders, indicating that genomic imprinting must occur in this region.
Famous quotes containing the words chromosome and/or partial:
“We become male automatically because of the Y chromosome and the little magic peanut, but if we are to become men we need the help of other men—we need our fathers to model for us and then to anoint us, we need our buddies to share the coming-of-age rituals with us and to let us join the team of men, and we need myths of heroes to inspire us and to show us the way.”
—Frank Pittman (20th century)
“You must not be partial in judging: hear out the small and the great alike; you shall not be intimidated by anyone, for the judgment is God’s.”
—Bible: Hebrew, Deuteronomy 1:17.