Charles Waterhouse may refer to:
- Charles Owen Waterhouse (1843–1917), English entomologist
- Charles Waterhouse (artist) (born 1924) American painter, illustrator and sculptor.
- Charles Waterhouse (British politician) (1893–1975), Conservative Member of Parliament 1924–1945 and 1950–1957
- Charles Waterhouse (hotelier), founder of Deerhurst Resort