Research
Several experimental treatments have shown promise in animal models. These include inhibitors of oxidosqualenecyclase and squalene synthase, cysteine protease inhibitors, dermaseptins collected from frogs in the genus Phyllomedusa (P. oreades and P. distincta), the sesquiterpene lactone dehydroleucodine (DhL), which affects the growth of cultured epimastigote–phase Trypanosoma cruzi, inhibitors of purine uptake, and inhibitors of enzymes involved in trypanothione metabolism. Hopefully, new drug targets may be revealed following the sequencing of the T. cruzi genome. A 2004 in vitro study suggests components of green tea (catechins) may be effective against T. cruzi.
Read more about this topic: Chagas Disease
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