Cell migration is a central process in the development and maintenance of multicellular organisms. Tissue formation during embryonic development, wound healing and immune responses all require the orchestrated movement of cells in particular directions to specific locations. Errors during this process have serious consequences, including mental retardation, vascular disease, tumor formation and metastasis. An understanding of the mechanism by which cells migrate may lead to the development of novel therapeutic strategies for controlling, for example, invasive tumour cells. Cells often migrate in response to specific external signals, including chemical signals and mechanical signals.
NFAT transcription factors are implicated in breast cancer, more specifically in the process of cell motility at the basis of metastasis formation. Indeed NFAT1 (NFATC2) and NFAT5 are pro-invasive and pro-migratory in breast carcinoma and NFAT3 (NFATc4) is an inhibitor of cell motility. NFAT1 regulates the expression of the TWEAKR and its ligand TWEAK with the Lipocalin 2 to increase breast cancer cell invasion and NFAT3 inhibits Lipocalin 2 expression to blunt the cell invasion.
Read more about Cell Migration: Studying Cell Migration, Molecular Processes At The Front, The Nucleus and Rear, Mutants, Polarity in Migrating Cells
Famous quotes containing the word cell:
“She that but little patience knew,
From childhood on, had now so much
A grey gull lost its fear and flew
Down to her cell and there alit,
And there endured her fingers’ touch
And from her fingers ate its bit.”
—William Butler Yeats (1865–1939)