Cask

CASK

Identifiers Symbols CASK; CAGH39; CAMGUK; CMG; FGS4; LIN2; MICPCH; MRXSNA; TNRC8 External IDs OMIM: 300172 MGI: 1309489 HomoloGene: 2736 GeneCards: CASK Gene EC number 2.7.11.1

Gene Ontology
Molecular function	• guanylate kinase activity • protein serine/threonine kinase activity • protein binding • calmodulin binding • ATP binding • neurexin family protein binding
Cellular component	• basement membrane • nuclear lamina • nucleolus • cytoplasm • cytosol • plasma membrane • cell-cell junction • actin cytoskeleton • basolateral plasma membrane • nuclear matrix • presynaptic membrane • cilium membrane
Biological process	• negative regulation of cell-matrix adhesion • cell adhesion • negative regulation of keratinocyte proliferation • positive regulation of transcription from RNA polymerase II promoter • negative regulation of wound healing • calcium ion import • positive regulation of calcium ion import • negative regulation of cellular response to growth factor stimulus
Sources: Amigo / QuickGO

RNA expression pattern More reference expression data Orthologs Species Human Mouse Entrez 8573 12361 Ensembl ENSG00000147044 ENSMUSG00000031012 UniProt O14936 O70589 RefSeq (mRNA) NM_001126054 NM_009806 RefSeq (protein) NP_001119526 NP_033936 Location (UCSC) Chr X:
41.37 – 41.78 Mb Chr X:
13.52 – 13.85 Mb PubMed search

Peripheral plasma membrane protein CASK is a protein that in humans is encoded by the CASK gene. This gene is also known by several other names: CMG 2 (CAMGUK protein 2), calcium/calmodulin-dependent serine protein kinase 3 and membrane-associated guanylate kinase 2.

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