Cardiac Action Potential - Major Currents

Major Currents

Major currents during the cardiac ventricular action potential
Ion Current (I) α subunit protein α subunit gene Phase / role
Na+ INa NaV1.5 SCN5A 0
Ca2+ ICa(L) CaV1.2 CACNA1C 0-2
K+ Ito1 KV4.2/4.3 KCND2/KCND3 1, notch
K+ IKs KV7.1 KCNQ1 2,3
K+ IKr KV11.1 (hERG) KCNH2 3
K+ IK1 Kir2.1/2.2/2.3 KCNJ2/KCNJ12/KCNJ4 3,4
Na+, Ca2+ INaCa 3Na+-1Ca2+-exchanger NCX1 (SLC8A1) ion homeostasis
Na+, K+ INaK 3Na+-2K+-ATPase ATP1A ion homeostasis
Ca2+ IpCa Ca2+-transporting ATPase ATP1B ion homeostasis

Read more about this topic:  Cardiac Action Potential

Famous quotes containing the words major and/or currents:

    “Our major universities are now stuck with an army of pedestrian, toadying careerists, Fifties types who wave around Sixties banners to conceal their record of ruthless, beaverlike tunneling to the top.”
    —Camille Paglia (b. 1947)

    “Rivers must have been the guides which conducted the footsteps of the first travelers. They are the constant lure, when they flow by our doors, to distant enterprise and adventure; and, by a natural impulse, the dwellers on their banks will at length accompany their currents to the lowlands of the globe, or explore at their invitation the interior of continents.”
    —Henry David Thoreau (1817–1862)