Burkitt's Lymphoma - Gene Targets

Gene Targets

Scientists from the National Cancer Institute (NCI), part of the National Institutes of Health, have uncovered a number of molecular signatures in Burkitt lymphoma, including unique genetic alterations that promote cell survival, that are not found in other lymphomas. These findings provide the first genetic evidence that Burkitt lymphoma is a cancer fundamentally distinct from other types of lymphoma. The identification of TCF3 and ID3 gene mutations in Burkitt led the researchers to identify a potent cell survival pathway that might be attacked therapeutically.