Bryostatin

Bryostatins are a group of macrolide lactones first isolated in the 1960s by George Pettit from extracts of a species of bryozoan, Bugula neritina. The structure of bryostatin 1 was determined in 1982. To date 20 different bryostatins have been isolated. Bryostatins are a potent modulators of protein kinase C. They are currently under investigation as anti-cancer agents and as a memory enhancing agent.