In physiology and medicine, the body surface area (BSA) is the measured or calculated surface of a human body. For many clinical purposes BSA is a better indicator of metabolic mass than body weight because it is less affected by abnormal adipose mass. Nevertheless, there have been several important critiques of the use of BSA in determining the dosage of medications with a narrow therapeutic index like many chemotherapy medications. Typically there is a 4-10 fold variation in cytotoxic drug clearance between individuals due to differing activity of drug elimination processes related to genetic and environmental factors. This can lead to significant overdosing and even more perniciously to underdosing (and increased risk of cancer recurrence). It is also thought to be a distorting factor in Phase I and II trials that may result in potentially helpful medications being prematurely rejected. The trend to personalized medicine is one approach to counter this weakness. Estimation of BSA is simpler than many measures of volume.
Read more about Body Surface Area: Uses, Calculation, Average Values
Famous quotes containing the words body, surface and/or area:
“Never did I read such tosh. As for the first two chapters we will let them pass, but the 3rd 4th 5th 6th—merely the scratching of pimples on the body of the bootboy at Claridges.”
—Virginia Woolf (1882–1941)
“We’ve forgotten what it’s like not to be able to reach the light switch. We’ve forgotten a lot of the monsters that seemed to live in our room at night. Nevertheless, those memories are still there, somewhere inside us, and can sometimes be brought to the surface by events, sights, sounds, or smells. Children, though, can never have grown-up feelings until they’ve been allowed to do the growing.”
—Fred Rogers (20th century)
“If you meet a sectary, or a hostile partisan, never recognize the dividing lines; but meet on what common ground remains,—if only that the sun shines, and the rain rains for both; the area will widen very fast, and ere you know it the boundary mountains, on which the eye had fastened, have melted into air.”
—Ralph Waldo Emerson (1803–1882)