In physiology and medicine, the body surface area (BSA) is the measured or calculated surface of a human body. For many clinical purposes BSA is a better indicator of metabolic mass than body weight because it is less affected by abnormal adipose mass. Nevertheless, there have been several important critiques of the use of BSA in determining the dosage of medications with a narrow therapeutic index like many chemotherapy medications. Typically there is a 4-10 fold variation in cytotoxic drug clearance between individuals due to differing activity of drug elimination processes related to genetic and environmental factors. This can lead to significant overdosing and even more perniciously to underdosing (and increased risk of cancer recurrence). It is also thought to be a distorting factor in Phase I and II trials that may result in potentially helpful medications being prematurely rejected. The trend to personalized medicine is one approach to counter this weakness. Estimation of BSA is simpler than many measures of volume.
Read more about Body Surface Area: Uses, Calculation, Average Values
Famous quotes containing the words body, surface and/or area:
“In adding up her assets, the ambitious lady calculated the worth of her beautiful body as coldly as everything else.”
—Mason Cooley (b. 1927)
“In the cold of Europe, under prudish northern fogs, except when slaughter is afoot, you only glimpse the crawling cruelty of your fellow men. But their rottenness rises to the surface as soon as they are tickled by the hideous fevers of the tropics.”
—Louis-Ferdinand Céline (1894–1961)
“The area [of toilet training] is one where a child really does possess the power to defy. Strong pressure leads to a powerful struggle. The issue then is not toilet training but who holds the reins—mother or child? And the child has most of the ammunition!”
—Dorothy Corkville Briggs (20th century)