In physiology and medicine, the body surface area (BSA) is the measured or calculated surface of a human body. For many clinical purposes BSA is a better indicator of metabolic mass than body weight because it is less affected by abnormal adipose mass. Nevertheless, there have been several important critiques of the use of BSA in determining the dosage of medications with a narrow therapeutic index like many chemotherapy medications. Typically there is a 4-10 fold variation in cytotoxic drug clearance between individuals due to differing activity of drug elimination processes related to genetic and environmental factors. This can lead to significant overdosing and even more perniciously to underdosing (and increased risk of cancer recurrence). It is also thought to be a distorting factor in Phase I and II trials that may result in potentially helpful medications being prematurely rejected. The trend to personalized medicine is one approach to counter this weakness. Estimation of BSA is simpler than many measures of volume.
Read more about Body Surface Area: Uses, Calculation, Average Values
Famous quotes containing the words body, surface and/or area:
“I found my brother’s body at the bottom there, where they had thrown it away on the rocks, by the river. Like an old, dirty rag nobody wants. He was dead. And I felt I had killed him. I turned back to give myself up.... Because if a man’s life can be lived so long and come out this way, like rubbish, then something was horrible, and had to be ended one way or another. And I decided to help.”
—Abraham Polonsky (b. 1910)
“How easily it falls, how easily I let drift
On the surface of morning feathers of self-reproach:
How easily I disperse the scolding of snow.”
—Philip Larkin (1922–1986)
“If you meet a sectary, or a hostile partisan, never recognize the dividing lines; but meet on what common ground remains,—if only that the sun shines, and the rain rains for both; the area will widen very fast, and ere you know it the boundary mountains, on which the eye had fastened, have melted into air.”
—Ralph Waldo Emerson (1803–1882)