In physiology and medicine, the body surface area (BSA) is the measured or calculated surface of a human body. For many clinical purposes BSA is a better indicator of metabolic mass than body weight because it is less affected by abnormal adipose mass. Nevertheless, there have been several important critiques of the use of BSA in determining the dosage of medications with a narrow therapeutic index like many chemotherapy medications. Typically there is a 4-10 fold variation in cytotoxic drug clearance between individuals due to differing activity of drug elimination processes related to genetic and environmental factors. This can lead to significant overdosing and even more perniciously to underdosing (and increased risk of cancer recurrence). It is also thought to be a distorting factor in Phase I and II trials that may result in potentially helpful medications being prematurely rejected. The trend to personalized medicine is one approach to counter this weakness. Estimation of BSA is simpler than many measures of volume.
Read more about Body Surface Area: Uses, Calculation, Average Values
Famous quotes containing the words body, surface and/or area:
“I had wild Jack for a lover;
Though like a road
That men pass over
My body makes no moan
But sings on:
All things remain in God.”
—William Butler Yeats (1865–1939)
“All beauties contain, like all possible phenomena, something eternal and something transitory,—something absolute and something particular. Absolute and eternal beauty does not exist, or rather it is only an abstraction skimmed from the common surface of different sorts of beauty. The particular element of each beauty comes from the emotions, and as we each have our own particular emotions, so we have our beauty.”
—Charles Baudelaire (1821–1867)
“... nothing is more human than substituting the quantity of words and actions for their character. But using imprecise words is very similar to using lots of words, for the more imprecise a word is, the greater the area it covers.”
—Robert Musil (1880–1942)