In physiology and medicine, the body surface area (BSA) is the measured or calculated surface of a human body. For many clinical purposes BSA is a better indicator of metabolic mass than body weight because it is less affected by abnormal adipose mass. Nevertheless, there have been several important critiques of the use of BSA in determining the dosage of medications with a narrow therapeutic index like many chemotherapy medications. Typically there is a 4-10 fold variation in cytotoxic drug clearance between individuals due to differing activity of drug elimination processes related to genetic and environmental factors. This can lead to significant overdosing and even more perniciously to underdosing (and increased risk of cancer recurrence). It is also thought to be a distorting factor in Phase I and II trials that may result in potentially helpful medications being prematurely rejected. The trend to personalized medicine is one approach to counter this weakness. Estimation of BSA is simpler than many measures of volume.
Read more about Body Surface Area: Uses, Calculation, Average Values
Famous quotes containing the words body, surface and/or area:
“And deep into her crystal body poured
The hot and sorrowful sweetness of the dust:
Whereof she wanders mad, being all unfit
For mortal love, that might not die of it.”
—Edna St. Vincent Millay (1892–1950)
“How easily it falls, how easily I let drift
On the surface of morning feathers of self-reproach:
How easily I disperse the scolding of snow.”
—Philip Larkin (1922–1986)
“Prosperous farmers mean more employment, more prosperity for the workers and the business men of ... every industrial area in the whole country.”
—Franklin D. Roosevelt (1882–1945)