History
The French Academy of Sciences originated the first recorded blind experiments in 1784: the Academy set up a commission to investigate the claims of animal magnetism proposed by Franz Mesmer. Headed by Benjamin Franklin and Antoine Lavoisier, the commission carried out experiments asking mesmerists to identify objects that had previously been filled with "vital fluid", including trees and flasks of water. The subjects were unable to do so. The commission went on to examine claims involving the curing of "mesmerized" patients. These patients showed signs of improved health, but the commission attributed this to the fact that these patients believed they would get better - the first scientific suggestion of the now well-known placebo effect.
In 1799 the British chemist Humphry Davy performed another early blind experiment. In studying the effects of nitrous oxide (laughing gas) on human physiology, Davy deliberately did not tell his subjects what concentration of the gas they were breathing, or whether they were breathing ordinary air.
Blind experiments went on to be used outside of purely scientific settings. In 1817, a committee of scientists and musicians compared a Stradivarius violin to one with a guitar-like design made by the naval engineer François Chanot. A well-known violinist played each instrument while the committee listened in the next room to avoid prejudice.
One of the first essays advocating a blinded approach to experiments in general came from Claude Bernard in the latter half of the 19th century, who recommended splitting any scientific experiment between the theorist who conceives the experiment and a naive (and preferably uneducated) observer who registers the results without foreknowledge of the theory or hypothesis being tested. This suggestion contrasted starkly with the prevalent Enlightenment-era attitude that scientific observation can only be objectively valid when undertaken by a well-educated, informed scientist.
Double-blind methods came into especial prominence in the mid-20th century.
Read more about this topic: Blind Experiment
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