The Bene Gesserit ( /ˈbɛniː ˈdʒɛsərɪt/ BEN-ee-JESS-ər-it) are a key social, religious, and political force in Frank Herbert's science fiction Dune universe. The group is described as an exclusive sisterhood whose members train their bodies and minds through years of physical and mental conditioning to obtain superhuman powers and abilities that can seem magical to outsiders. Acolytes who have acquired the breadth of Bene Gesserit abilities are called Reverend Mothers within the organization's ranks. Some of these fictional powers are analyzed and deconstructed from a real world scientific perspective in the book The Science of Dune (2008).
Sometimes called "witches" due to their secretive nature and misunderstood powers, the Bene Gesserit are loyal only to themselves. However, to attain their goals and avoid outside interference, they often screen themselves with the illusion of being loyal to other groups or individuals. Their every move is calculated toward a result. As the skills of a Bene Gesserit are as desirable as an alliance with the Sisterhood itself, they are able to charge a fee to school the females from Great Houses, and install some of their initiates as wives and concubines to their advantage. In 1965's Dune, the Princess Irulan is quoted (via epigraph):
"The Reverend Mother must combine the seductive wiles of a courtesan with the untouchable majesty of a virgin goddess, holding these attributes in tension so long as the powers of her youth endure. For when youth and beauty have gone, she will find that the place-between, once occupied by tension, has become a wellspring of cunning and resourcefulness." —from Muad'Dib, Family Commentaries by the Princess IrulanRead more about Bene Gesserit: Litany Against Fear, Origin of The Name