Cyanuric Chloride Assisted Beckmann Reaction
Beckmann reaction is known to be catalyzed by cyanuric chloride and zinc chloride co-catalyst. For example, cyclododecanone can be converted to the corresponding lactam, a monomer for the production of Nylon 12.
The reaction mechanism for this reaction is based on a catalytic cycle with cyanuric chloride activating the hydroxyl group via a nucleophilic aromatic substitution. The reaction product is dislodged and replaced by new reactant via an intermediate Meisenheimer complex.
Read more about this topic: Beckmann Rearrangement
Famous quotes containing the words assisted and/or reaction:
“To anticipate, not the sunrise and the dawn merely, but, if possible, Nature herself! How many mornings, summer and winter, before yet any neighbor was stirring about his business, have I been about mine! No doubt, many of my townsmen have met me returning from this enterprise, farmers starting for Boston in the twilight, or woodchoppers going to their work. It is true, I never assisted the sun materially in his rising, but, doubt not, it was of the last importance only to be present at it.”
—Henry David Thoreau (1817–1862)
“In contrast to revenge, which is the natural, automatic reaction to transgression and which, because of the irreversibility of the action process can be expected and even calculated, the act of forgiving can never be predicted; it is the only reaction that acts in an unexpected way and thus retains, though being a reaction, something of the original character of action.”
—Hannah Arendt (1906–1975)