Background
Alexander set out into Asia in 334 BC and defeated the local Persian satraps at the Battle of the Granicus. He then proceeded to occupy all of Asia Minor, with the idea of capturing all coastal settlements so as to negate the power of the vastly superior Persian fleet. He captured several important settlements such as Miletus in 334 BC and Halicarnassus, a siege lasting four months, starting in late December the same year. While Alexander was in Tarsus he heard of Darius massing a great army in Babylon. If Darius were to reach the Gulf of Issus he could use the support from the Persian fleet under Pharnabazus still operating in the Mediterranean Sea, thus easing his supply and possibly landing troops behind the enemy. Alexander kept his main army at Tarsus but sent Parmenion ahead to occupy the coast around Issus. In November, Alexander received reports that the great Persian army had advanced into Syria, to a town named Sochi. Alexander decided to mass his scattered army and advance south from Issus through the Pass of Jonah.
Darius knew that Parmenion held the Pass of Jonah and thus chose a northern route of advance. The Persians captured Issus without opposition, and cut off the hands of all the sick and wounded that Alexander had left behind. Now Darius found out he had placed his army behind the Macedonians and had cut their supply lines. He then advanced to the south and got no further than the river Pinarus before his scouts spotted Alexander marching north. Darius had to set up camp on this narrow coastal plain.
Read more about this topic: Battle Of Issus
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