Function and Importance
The primary function of the basement membrane is to anchor down the epithelium to its loose connective tissue underneath. This is achieved by cell-matrix adhesions through substrate adhesion molecules (SAMs).
The basement membrane acts as a mechanical barrier, preventing malignant cells from invading the deeper tissues. Early stages of malignancy that are thus limited to the epithelial layer by the basement membrane are called carcinoma in situ.
The basement membrane is also essential for angiogenesis (development of new blood vessels). Basement membrane proteins have been found to accelerate differentiation of endothelial cells.
The most notable examples of basement membranes is in the glomerular filtration of the kidney, by the fusion of the basal lamina from the endothelium of glomerular capillaries and the basal lamina of the epithelium of the Bowman's capsule, and between lung alveoli and pulmonary capillaries, by the fusion of the basal lamina of the lung alveoli and of the basal lamina of the lung capillaries, which is where oxygen and CO2 diffusion happens.
Read more about this topic: Basement Membrane
Famous quotes containing the words function and/or importance:
“It is not the function of our Government to keep the citizen from falling into error; it is the function of the citizen to keep the Government from falling into error.”
—Robert H. [Houghwout] Jackson (1892–1954)
“What is done for science must also be done for art: accepting undesirable side effects for the sake of the main goal, and moreover diminishing their importance by making this main goal more magnificent. For one should reform forward, not backward: social illnesses, revolutions, are evolutions inhibited by a conserving stupidity.”
—Robert Musil (1880–1942)