Biological Dangers and Precautions
Because of the high reactivity of the metal toxicological data are available only for compounds. Water-soluble barium compounds are poisonous. At low doses, barium ions act as a muscle stimulant, whereas higher doses affect the nervous system, causing cardiac irregularities, tremors, weakness, anxiety, dyspnea and paralysis. This may be due to the ability of Ba2+ to block potassium ion channels, which are critical to the proper function of the nervous system. Other target organs for water-soluble barium compounds (i.e., barium ions) are eyes, immune system, heart, respiratory system, and skin. They affect the body strongly, causing, for example, blindness and sensitization.
Barium is not carcinogenic, and it does not bioaccumulate. However, inhaled dust containing insoluble barium compounds can accumulate in the lungs, causing a benign condition called baritosis. For comparison to the soluble poisons, the insoluble sulfate is nontoxic and is thus not classified as a dangerous good.
To avoid a potentially vigorous chemical reaction, barium metal is kept under argon or mineral oils. Contact with air is dangerous, as it may cause ignition. Moisture, friction, heat, sparks, flames, shocks, static electricity, reactions with oxidizers and acids should be avoided. Everything that may make contact with barium should be grounded. Those who work with the metal should wear pre-cleaned non-sparking shoes, flame-resistant rubber clothes, rubber gloves, apron, goggles, and a gas mask; they are not allowed to smoke in the working area and must wash themselves after handling barium.
Read more about this topic: Barium Compounds
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