Ayub Khan may refer to:
- Ayyub Khan (Kipchak leader) (?-1117), Kipchak leader
- Ghazi Ayub Khan (1857-1914), who fought against Britain in the Second Anglo-Afghan War
- Ayub Khan (actor), Indian film and television actor and nephew of Bollywood legend Dilip Kumar
- Gohar Ayub Khan
- Ayub Khan (Field Marshal) (1907-1974), President of Pakistan
- Omar Ayub Khan