Asaf Khan (Urdu: آصف خان) may refer to:
- Asaf Khan I or Khwaja Abdul Majid (during the Reign of Akbar)
- Asaf Khan II or Khwaja Mirza Ghiyas-ud-din Ali (during the Reign of Akbar)
- Asaf Khan III or Mirza Jafar Beg, nephew of Asaf Khan II (during the Reign of Jahangir)
- Asaf Khan IV or Abul Hasan son-in-law of Asaf Khan II (during the Reign of Jahangir & Shah Jahan)