Mechanism of Action
– Not completely understood – May inhibit iodination of tyrosyl residues in thyroglobulin. – It is thought that they inhibit the thyroperoxidase- catalysed oxidation reactions by acting as substrates for the postulated peroxidase-iodinium complex, thus competitively inhibiting the interaction with tyrosine. • Propylthiouracil additionally may reduce the deiodination of T4 in to T3 in peripheral tissues.
Read more about this topic: Antithyroid Drugs
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