Anti-nuclear Antibody - ANA Classification

ANA Classification

Following detection of a high titer of ANAs (e.g. 1:160), various subtypes are determined. This is typically done on cells of the HEp-2 cell line. Examples include

• Anti-ENA (Extractable nuclear antigen)
  • Anti-Ro (SS-A)
  • Anti-La (SS-B)
  • Anti-Sm (Smith antigen)
  • Anti-nRNP (nuclear ribonucleoproteins)
  • Anti Scl-70 (topoisomerase I)
  • Anti-Jo
• Anti-gp-210 (nuclear pore gp-210)
• Anti-p62 (Nucleoporin 62)
• Anti-dsDNA (double-stranded DNA)
• Anti-centromere