Role in Health and Disease
Nicotinic acetylcholine receptors can be blocked by curare, hexamethonium and toxins present in the venoms of snakes and shellfishes, like α-bungarotoxin. Drugs such as the neuromuscular blocking agents bind reversibly to the nicotinic receptors in the neuromuscular junction and are used routinely in anaesthesia.
Nicotinic receptors are the primary mediator of the effects of nicotine. In myasthenia gravis, the receptor at NMJ is targeted by antibodies, leading to muscle weakness. Muscarinic acetylcholine receptors can be blocked by the drugs atropine and scopolamine.
Read more about this topic: Acetylcholine Receptor
Famous quotes containing the words role in, role, health and/or disease:
“Certainly parents play a crucial role in the lives of individuals who are intellectually gifted or creatively talented. But this role is not one of active instruction, of teaching children skills,... rather, it is support and encouragement parents give children and the intellectual climate that they create in the home which seem to be the critical factors.”
—David Elkind (20th century)
“So successful has been the camera’s role in beautifying the world that photographs, rather than the world, have become the standard of the beautiful.”
—Susan Sontag (b. 1933)
“A comfortable house is a great source of happiness. It ranks immediately after health and a good conscience.”
—Sydney Smith (1771–1845)
“Whoever grows angry amid troubles applies a drug worse than the disease and is a physician unskilled about misfortunes.”
—Sophocles (497–406/5 B.C.)