Role in Health and Disease
Nicotinic acetylcholine receptors can be blocked by curare, hexamethonium and toxins present in the venoms of snakes and shellfishes, like α-bungarotoxin. Drugs such as the neuromuscular blocking agents bind reversibly to the nicotinic receptors in the neuromuscular junction and are used routinely in anaesthesia.
Nicotinic receptors are the primary mediator of the effects of nicotine. In myasthenia gravis, the receptor at NMJ is targeted by antibodies, leading to muscle weakness. Muscarinic acetylcholine receptors can be blocked by the drugs atropine and scopolamine.
Read more about this topic: Acetylcholine Receptor
Famous quotes containing the words role, health and/or disease:
“To win by strategy is no less the role of a general than to win by arms.”
—Julius Caesar [Gaius Julius Caesar] (100–44 B.C.)
“Most days I feel like an acrobat high above a crowd out of which my own parents, my in-laws, potential employers, phantoms of “other women who do it” and a thousand faceless eyes stare up.”
—Anonymous Mother. Ourselves and Our Children, by Boston Women’s Health Book Collective, ch. 2 (1978)
“His poor self,
A dedicated beggar to the air,
With his disease of all-shunned poverty,
Walks, like contempt, alone.”
—William Shakespeare (1564–1616)