Role in Health and Disease
Nicotinic acetylcholine receptors can be blocked by curare, hexamethonium and toxins present in the venoms of snakes and shellfishes, like α-bungarotoxin. Drugs such as the neuromuscular blocking agents bind reversibly to the nicotinic receptors in the neuromuscular junction and are used routinely in anaesthesia.
Nicotinic receptors are the primary mediator of the effects of nicotine. In myasthenia gravis, the receptor at NMJ is targeted by antibodies, leading to muscle weakness. Muscarinic acetylcholine receptors can be blocked by the drugs atropine and scopolamine.
Read more about this topic: Acetylcholine Receptor
Famous quotes containing the words role, health and/or disease:
“Friends serve central functions for children that parents do not, and they play a critical role in shaping children’s social skills and their sense of identity. . . . The difference between a child with close friendships and a child who wants to make friends but is unable to can be the difference between a child who is happy and a child who is distressed in one large area of life.”
—Zick Rubin (20th century)
“The health of the soul is something we can be no more sure of than that of the body; and though a man may seem far from the passions, yet he is in as much danger of falling into them as one in a perfect state of health of having a fit of sickness.”
—François, Duc De La Rochefoucauld (1613–1680)
“Hastiness and superficiality are the psychic diseases of the twentieth century, and more than anywhere else this disease is reflected in the press.”
—Alexander Solzhenitsyn (b. 1918)