Role in Health and Disease
Nicotinic acetylcholine receptors can be blocked by curare, hexamethonium and toxins present in the venoms of snakes and shellfishes, like α-bungarotoxin. Drugs such as the neuromuscular blocking agents bind reversibly to the nicotinic receptors in the neuromuscular junction and are used routinely in anaesthesia.
Nicotinic receptors are the primary mediator of the effects of nicotine. In myasthenia gravis, the receptor at NMJ is targeted by antibodies, leading to muscle weakness. Muscarinic acetylcholine receptors can be blocked by the drugs atropine and scopolamine.
Read more about this topic: Acetylcholine Receptor
Famous quotes containing the words role, health and/or disease:
“The addition of a helpless, needy infant to a couple’s life limits freedom of movement, changes role expectancies, places physical demands on parents, and restricts spontaneity.”
—Jerrold Lee Shapiro (20th century)
“However strongly they resist it, our kids have to learn that as adults we need the companionship and love of other adults. The more direct we are about our needs, the easier it may be for our children to accept those needs. Their jealousy may come from a fear that if we adults love each other we might not have any left for them. We have to let them know that it’s a different kind of love.”
—Ruth Davidson Bell. Ourselves and Our Children, by Boston Women’s Health Book Collective, ch. 3 (1978)
“The fantasies inspired by TB in the last century, by cancer now, are responses to a disease thought to be intractable and capricious—that is, a disease not understood—in an era in which medicine’s central premise is that all diseases can be cured.”
—Susan Sontag (b. 1933)