Role in Health and Disease
Nicotinic acetylcholine receptors can be blocked by curare, hexamethonium and toxins present in the venoms of snakes and shellfishes, like α-bungarotoxin. Drugs such as the neuromuscular blocking agents bind reversibly to the nicotinic receptors in the neuromuscular junction and are used routinely in anaesthesia.
Nicotinic receptors are the primary mediator of the effects of nicotine. In myasthenia gravis, the receptor at NMJ is targeted by antibodies, leading to muscle weakness. Muscarinic acetylcholine receptors can be blocked by the drugs atropine and scopolamine.
Read more about this topic: Acetylcholine Receptor
Famous quotes containing the words role in, role, health and/or disease:
“If women’s role in life is limited solely to housewife/mother, it clearly ends when she can no longer bear more children and the children she has borne leave home.”
—Betty Friedan (20th century)
“Whether or not you have children yourself, you are a parent to the next generation. If we can only stop thinking of children as individual property and think of them as the next generation, then we can realize we all have a role to play.”
—Charlotte Davis Kasl (20th century)
“The fact that the mental health establishment has equated separation with health, equated women’s morality with soft-heartedness, and placed mothers on the psychological hot seat has taken a toll on modern mothers.”
—Ron Taffel (20th century)
“Your responsibility as a parent is not as great as you might imagine. You need not supply the world with the next conqueror of disease or a major movie star. If your child simply grows up to be someone who does not use the word “collectible” as a noun, you can consider yourself an unqualified success.”
—Fran Lebowitz (20th century)