Role in Health and Disease
Nicotinic acetylcholine receptors can be blocked by curare, hexamethonium and toxins present in the venoms of snakes and shellfishes, like α-bungarotoxin. Drugs such as the neuromuscular blocking agents bind reversibly to the nicotinic receptors in the neuromuscular junction and are used routinely in anaesthesia.
Nicotinic receptors are the primary mediator of the effects of nicotine. In myasthenia gravis, the receptor at NMJ is targeted by antibodies, leading to muscle weakness. Muscarinic acetylcholine receptors can be blocked by the drugs atropine and scopolamine.
Read more about this topic: Acetylcholine Receptor
Famous quotes containing the words role, health and/or disease:
“Scholars who become politicians are usually assigned the comic role of having to be the good conscience of state policy.”
—Friedrich Nietzsche (1844–1900)
“I am astonished at the singular pertinacity and endurance of our lives. The miracle is, that what is is, when it is so difficult, if not impossible, for anything else to be; that we walk on in our particular paths so far, before we fall on death and fate, merely because we must walk in some path; that every man can get a living, and so few can do anything more. So much only can I accomplish ere health and strength are gone, and yet this suffices.”
—Henry David Thoreau (1817–1862)
“It is useless to check the vain dunce who has caught the mania of scribbling, whether prose or poetry, canzonets or criticisms,—let such a one go on till the disease exhausts itself. Opposition like water, thrown on burning oil, but increases the evil, because a person of weak judgment will seldom listen to reason, but become obstinate under reproof.”
—Sarah Josepha Buell Hale 1788–1879, U.S. novelist, poet and women’s magazine editor. American Ladies Magazine, pp. 36-40 (December 1828)