Role in Health and Disease
Nicotinic acetylcholine receptors can be blocked by curare, hexamethonium and toxins present in the venoms of snakes and shellfishes, like α-bungarotoxin. Drugs such as the neuromuscular blocking agents bind reversibly to the nicotinic receptors in the neuromuscular junction and are used routinely in anaesthesia.
Nicotinic receptors are the primary mediator of the effects of nicotine. In myasthenia gravis, the receptor at NMJ is targeted by antibodies, leading to muscle weakness. Muscarinic acetylcholine receptors can be blocked by the drugs atropine and scopolamine.
Read more about this topic: Acetylcholine Receptor
Famous quotes containing the words role, health and/or disease:
“You are pitiful isolated individuals; you are bankrupts; your role is played out. Go where you belong from now on—into the dustbin of history!”
—Leon Trotsky (1879–1940)
“Health is a state of complete physical, mental and social well-being, and not merely the absence of disease or infirmity.”
—Constitution of the World Health Organization.
“Sadism is not an infectious disease that strikes a person all of a sudden. It has a long prehistory in childhood and always originates in the desperate fantasies of a child who is searching for a way out of a hopeless situation.”
—Alice Miller (20th century)