In enzymology, a 6-carboxyhexanoate-CoA ligase (EC 6.2.1.14) is an enzyme that catalyzes the chemical reaction
- ATP + 6-carboxyhexanoate + CoA AMP + diphosphate + 6-carboxyhexanoyl-CoA
The 3 substrates of this enzyme are ATP, 6-carboxyhexanoate, and CoA, whereas its 3 products are AMP, diphosphate, and 6-carboxyhexanoyl-CoA.
This enzyme belongs to the family of ligases, specifically those forming carbon-sulfur bonds as acid-thiol ligases. The systematic name of this enzyme class is 6-carboxyhexanoate:CoA ligase (AMP-forming). Other names in common use include 6-carboxyhexanoyl-CoA synthetase, and pimelyl-CoA synthetase. This enzyme participates in biotin metabolism.