Cast
- Adam Sandler as Henry Roth, a marine veterinarian with a talent for wooing women and a fear of commitment
- Drew Barrymore as Lucy Whitmore, Henry's love interest
- Rob Schneider as Ula, Henry's marijuana-smoking, native Hawaiian assistant. Ula is unhappily married to an overweight native woman and has five young, athletically talented children.
- Sean Astin as Doug Whitmore, Lucy's older brother, a lisping, steroid-dependent bodybuilder
- Blake Clark as Marlin Whitmore, Lucy's father, a professional fisherman
- Lusia Strus as Alexa, Henry's ambiguously gendered assistant
- Dan Aykroyd as Dr. Keats, a physician specializing in brain disorders
- Amy Hill as Sue, the Hukilau café manager and friend of Lucy and her late mother
- Pomaika'i Brown as Nick, the Hukilau café chef.
- Allen Covert as Ten-Second Tom, a hospital patient with severe memory impairment
- Missi Pyle as Noreen, tax attorney Henry meets at a bar but then tries to fix up with Alexa
- Maya Rudolph as Stacy, pregnant woman at beach party
- Kevin James as Factory Worker
- Lynn Collins as Linda
- Joshua Seth as a Painter (uncredited)
- Dee Bradley Baker as a man at the restaurant (uncredited)
Read more about this topic: 50 First Dates
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—Bible: New Testament Jesus, in Mark 11:23.
Matthew 21:21 also refers to this speech.