5-oxopent-3-ene-1,2,5-tricarboxylate Decarboxylase

In enzymology, a 5-oxopent-3-ene-1,2,5-tricarboxylate decarboxylase (EC 4.1.1.68) is an enzyme that catalyzes the chemical reaction

5-oxopent-3-ene-1,2,5-tricarboxylate 2-oxohept-3-enedioate + CO₂

Hence, this enzyme has one substrate, 5-oxopent-3-ene-1,2,5-tricarboxylate, and two products, 2-oxohept-3-enedioate and CO₂.

This enzyme belongs to the family of lyases, specifically the carboxy-lyases, which cleave carbon-carbon bonds. The systematic name of this enzyme class is 5-oxopent-3-ene-1,2,5-tricarboxylate carboxy-lyase (2-oxohept-3-enedioate-forming). Other names in common use include 5-carboxymethyl-2-oxo-hex-3-ene-1,6-dioate decarboxylase, and 5-oxopent-3-ene-1,2,5-tricarboxylate carboxy-lyase. This enzyme participates in tyrosine metabolism.