5-lipoxygenase-activating Protein

5-lipoxygenase-activating Protein

Identifiers Symbols ALOX5AP; FLAP External IDs OMIM: 603700 MGI: 107505 HomoloGene: 1231 ChEMBL: 4550 GeneCards: ALOX5AP Gene

Gene Ontology
Molecular function arachidonate 5-lipoxygenase activity
glutathione transferase activity
leukotriene-C4 synthase activity
protein binding
enzyme activator activity
enzyme binding
protein homodimerization activity
protein heterodimerization activity
protein N-terminus binding
arachidonic acid binding
Cellular component nuclear envelope
endoplasmic reticulum
endoplasmic reticulum membrane
integral to membrane
nuclear membrane
Biological process leukotriene production involved in inflammatory response
glutathione biosynthetic process
leukotriene biosynthetic process
protein homotrimerization
cellular response to calcium ion
Sources: Amigo / QuickGO
Orthologs Species Human Mouse Entrez 241 11690 Ensembl ENSG00000132965 ENSMUSG00000060063 UniProt P20292 P30355 RefSeq (mRNA) NM_001204406.1 NM_009663.1 RefSeq (protein) NP_001191335.1 NP_033793.1 Location (UCSC) Chr 13:
31.31 – 31.34 Mb Chr 5:
149.27 – 149.29 Mb PubMed search


Arachidonate 5-lipoxygenase-activating protein also known as 5-lipoxygenase activating protein, or FLAP, is a protein that in humans is encoded by the ALOX5AP gene.

Read more about 5-lipoxygenase-activating Protein:  Function, Clinical Significance, Inhibitors

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