5-HT4 Receptor - Ligands

Ligands

Several drugs which act as 5-HT₄ selective agonists have recently been introduced into use in both scientific research and clinical medicine. Some drugs which act as 5-HT₄ agonists are also active as 5-HT₃ antagonists, such as mosapride, metoclopramide, renzapride and zacopride, and so these compounds cannot be considered highly selective. Research in this area is ongoing.

SB-207,145 radiolabeled with carbon-11 is used as a radioligand for 5-HT₄ in positron emission tomography pig and human studies.