Role in Virus Endocytosis
5-HT2A may be a necessary receptor for clathrin mediated endocytosis of the human polyoma virus called JC virus, the causative agent of progressive multifocal leukoencephalopathy (PML), that enters cells such as oligodendrocytes, astrocytes, B lymphocytes, and kidney epithelial cells. These cells need to express both the alpha 2-6–linked sialic acid component of the 5HT2A receptor in order to endocytose JCV.
Read more about this topic: 5-HT2A Receptor
Famous quotes containing the words role in, role and/or virus:
“So successful has been the camera’s role in beautifying the world that photographs, rather than the world, have become the standard of the beautiful.”
—Susan Sontag (b. 1933)
“When things turn out pretty much as expected, parents give little thought to how much they have influenced the outcome. When things don’t turn out as expected, parents give a great deal of thought to the role they play.”
—Arlene Harder (20th century)
“If I knew for a certainty that a man was coming to my house with the conscious design of doing me good, I should run for my life ... for fear that I should get some of his good done to me,—some of its virus mingled with my blood.”
—Henry David Thoreau (1817–1862)