5-HT2A Receptor - Effects

Effects

Physiological processes mediated by the receptor include:

  • CNS: neuronal excitation, behavioural effects, learning, anxiety
  • smooth muscle: contraction (in gastrointestinal tract & bronchi)
  • vasoconstriction / vasodilatation
  • platelets: aggregation
  • Activation of the 5-HT2A receptor with DOI produces superpotent anti-inflammatory effects in cardiovascular related tissues, as well as potent anti-inflammatory effects in non-cardiovascular tissues. Other 5-HT2A agonists like LSD also have potent anti-inflammatory effects against TNF-alpha-induced inflammation.
  • Activation of the 5-HT2A receptor in hypothalamus causes increases in hormonal levels of oxytocin, prolactin, ACTH, corticosterone, and renin.

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