5-carboxymethyl-2-hydroxymuconic-semialdehyde Dehydrogenase

In enzymology, a 5-carboxymethyl-2-hydroxymuconic-semialdehyde dehydrogenase (EC 1.2.1.60) is an enzyme that catalyzes the chemical reaction

5-carboxymethyl-2-hydroxymuconate semialdehyde + H2O + NAD+ 5-carboxymethyl-2-hydroxymuconate + NADH + 2 H+

The 3 substrates of this enzyme are 5-carboxymethyl-2-hydroxymuconate semialdehyde, H2O, and NAD+, whereas its 3 products are 5-carboxymethyl-2-hydroxymuconate, NADH, and H+.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the aldehyde or oxo group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is 5-carboxymethyl-2-hydroxymuconic-semialdehyde:NAD+ oxidoreductase. This enzyme is also called carboxymethylhydroxymuconic semialdehyde dehydrogenase. This enzyme participates in tyrosine metabolism.

Read more about 5-carboxymethyl-2-hydroxymuconic-semialdehyde Dehydrogenase:  Structural Studies