Production and Inhibition
The enzyme is produced in many tissues in both males and females especially in tissues of the reproductive tract, testis and ovary, namely the skin, seminal vesicles, prostate, epididymis and many organs.
Inhibition of 5α-reductase results in decreased conversion of T to DHT, increased levels of testosterone, and, perhaps, increased levels of estradiol. Gynecomastia, erectile dysfunction and depression, are only a few of the possible side-effects of 5α-reductase inhibition. Long term side effects, that continued even after discontinuation of the drug, are called "Post-Finasteride Syndrome".
Read more about this topic: 5-alpha Reductase
Famous quotes containing the word production:
“The growing of food and the growing of children are both vital to the family’s survival.... Who would dare make the judgment that holding your youngest baby on your lap is less important than weeding a few more yards in the maize field? Yet this is the judgment our society makes constantly. Production of autos, canned soup, advertising copy is important. Housework—cleaning, feeding, and caring—is unimportant.”
—Debbie Taylor (20th century)