Production and Inhibition
The enzyme is produced in many tissues in both males and females especially in tissues of the reproductive tract, testis and ovary, namely the skin, seminal vesicles, prostate, epididymis and many organs.
Inhibition of 5α-reductase results in decreased conversion of T to DHT, increased levels of testosterone, and, perhaps, increased levels of estradiol. Gynecomastia, erectile dysfunction and depression, are only a few of the possible side-effects of 5α-reductase inhibition. Long term side effects, that continued even after discontinuation of the drug, are called "Post-Finasteride Syndrome".
Read more about this topic: 5-alpha Reductase
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—Raoul Vaneigem (b. 1934)
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—Charles Darwin (1809–1882)